Twelvetrees, who won the 2014/15 Challenge Cup with his current employers, starts in midfield with Tom Seabrook, as Ben Meehan returns to form a half-back partnership with Adam Hastings.

Santiago Socino, who dotted down in Gloucester’s EPCR Challenge Cup Round 4 win over USAP, returns to the front row alongside Harry Elrington, whilst Jack Clement replaces Lewis Ludlow in the back row.

Fellow EPCR Challenge Cup hopefuls Northampton welcome back Dan Biggar to their line-up, as the British and Irish Lion starts in a half-back partnership with Alex Mitchell.

Rory Hutchinson has been added to the Northampton back three, and in the forwards, Teimana Harrison starts in a back row with Alex Coles and Juarno Augustus.

Meanwhile, there is another all-EPCR Challenge Cup clash at the Brentford Community Stadium as London Irish face Worcester Warriors in the Premiership.

Kyle Rowe starts on the wing for the hosts, as Benhard van Rensburg returns to the midfield with Curtis Rona. Facundo Gigena and Ollie Hoskins start in the front row, with Juan Martín Gonzalez and Sean O’Brien added to The Exiles’ back row.

Visitors Worcester have named wing Duhan van der Merwe in their starting XV, with Ashley Beck starting in midfield, as Billy Searle and Willi Heinz form the half-back partnership.

Ethan Walker and Isaac Miller come into the front row, with Justin Clegg and Andrew Kitchener making up the second row.

Elsewhere in the Premiership, Saracens take on Leicester Tigers and Bath Rugby entertain Bristol Bears at The Recreation Ground.

In the United Rugby Championship, Benetton Rugby take on Leinster Rugby, while Glasgow Warriors head to Scarlets and Dragons face Munster Rugby.

At Parc des Sports Aguiléra, Biarritz Olympique will face fellow EPCR Challenge Cup side RC Toulon in the TOP 14, as Castres Olympique host Montpellier Hérault Rugby and Section Paloise travel to Union Bordeaux-Bègles. CA Brive face Stade Rochelais with USAP hosting Racing 92 and Lyon take on ASM Clermont Auvergne.

On Sunday, Zebre Parma travel to the Swansea.com Stadium as they face Ospreys in the United Rugby Championship.

Challenge Cup winner Billy Twelvetrees will return to the Gloucester Rugby starting XV on Saturday as George Skivington’s men face Northampton Saints in the Gallagher Premiership.