Quins, who open their 2022-23 EPCR campaign with a trip to Durban to take on Sharks, recall the England international duo of wing Joe Marchant and prop Will Collier to the starting XV. However, fly-half Marcus Smith remains on mandated rest.

Three-time European champions Saracens, who host Edinburgh Rugby in the opening round of fixtures on the weekend of December 9-11, hand cap number 150 to centre Nick Tompkins, while Hugh Tizard makes his competitive debut for the club in the second row.

Elsewhere, Pool B foes Northampton Saints and London Irish do battle at cinch stadium at Franklin's Gardens.

Northampton, who face a trip to Heineken Champions Cup holders Stade Rochelais in the opening round of pool stage action, welcome back club captain Dan Biggar to the starting lineup, while Scotland international Rory Hutchinson also makes the XV for the first time this season.

London Irish host Montpellier Hérault Rugby in Round 1 and will hoping to lay down a marker against their pool rivals Northampton. Wing Ben Loader and No.8 Matt Rogerson make their first starts of the season.

Meanwhile, Sale Sharks travel to Bath Rugby. Summer signing from Exeter Chiefs Jonny Hill has been named in the starting XV for the first time in the only change for Alex Sanderson’s side.

Leicester Tigers host Newcastle Falcons, Ollie Chessum, Joe Hayes, Jack van Poortvliet and Guy Porter set to make their seasonal bows after returning from England duty.

On Sunday, 2020 Heineken Champions Cup winners Exeter Chiefs travel to Worcester Warriors.

Last season’s Heineken Champions Cup runners up Leinster Rugby travel to Zebre Parma in the opening round of the United Rugby Championship (URC). Rhys Ruddock captains the side, with second row Jason Jenkins and centre Charle Ngatai handed debuts.

Fellow Irish province Munster Rugby travel to Cardiff Rugby - head coach Graham Rowntree takes charge for the first time and hands a competitive debut to Malakai Fekitoa.

Vodacom Bulls, who make their Heineken Champions Cup bow against Lyon in December, travel to South African rivals Lions and start three debutants, in No.8 Mihlali Mosi, winger S’bu Nkosi and full-back Wandisile Simelane.

Scarlets host Ospreys, Wales’ lone representative in the Heineken Champions Cup, at Parc y Scarlets, flanker Justin Tipuric returning to captain the side. Jack Walsh could make his Ospreys debut from the replacements bench.

Edinburgh host Welsh opposition in the form of Dragons at Dam Health Stadium, Fijian no.8 Viliame Mata returning from a nine-month injury lay-off for the Scottish region, while Uster Rugby, who travel to Sale in the opening round of the Heineken Champions Cup, host Connacht Rugby, summer signing Jeff Toomaga-Allen set for a first appearance from the bench.

In the TOP 14, Union Bordeaux-Bègles and Castres Olympique headline in an all-Pool A matchup. Elsewhere Montpellier travel to CA Brive, La Rochelle host USAP, Lyon travel to Racing 92 and five-time European champions Stade Toulousain visit Section Paloise.

On Sunday Toulon host ASM Clermont Auvergne.

Heineken Champions Cup Pool A rivals Harlequins and Saracens square off at Twickenham Stoop on Saturday afternoon in the Gallagher Premiership.