Six former tournament winners are also in contention to win the coveted silverware again following the announcement of the dates, kick-off times and broadcast coverage of the home and away matches at the start of the Heineken Champions Cup knockout stage, as well as details of the EPCR Challenge Cup Round 5 pool stage fixtures.

With aggregate scores over the two contests deciding the Round of 16 winners, dramatic outcomes in packed stadiums are certain to be the order of the day as the four highest-ranked clubs in each pool are scheduled to play their second leg matches at home.

Holders, Stade Toulousain, are moving their first leg fixture against URC front runners, Ulster Rugby, to the 33,000-capacity Le Stadium on Saturday, 9 April with the action live on BT Sport, while the second leg goes ahead at the Kingspan Stadium on Saturday, 16 April.

Racing 92, the No 1-ranked qualifier from Pool A, make the short journey to Stade Jean Bouin for their first leg clash with Stade Fran9ais Paris also on Saturday, 9 April with the decisive second leg at Paris La Défense Arena on Sunday, 17 April.

Pool B table-toppers and current Gallagher Premiership leaders, Leicester Tigers, relaunch their bid for the title which has eluded them since 2002 when they travel to Stade Marcel-Michelin to face ASM Clermont Auvergne on Sunday, 10 April ahead of the second meeting at Mattioli Woods Welford Road on Saturday, 16 April.

While all Round of 16 matches will be live on BT Sport, additional free-to-air coverage on Channel 4 and Virgin Media in the UK and Ireland is scheduled for the first leg tie between Sale Sharks and Bristol Bears on Saturday, 9 April and for the second leg head-to-head between Harlequins and Montpellier Hérault Rugby on Saturday, 16 April.

Four-time winners, Leinster Rugby, kick off the historic Round of 16 on Friday, 8 April with an all-Irish confrontation against Connacht Rugby at The Sportsground with the return leg set to go ahead at the 51,000-capacity Aviva Stadium on Friday, 15 April.

In the event of drawn matches or equal aggregate scores at the end of normal time during the knockout stage of the Heineken Champions Cup, extra-time will be played with the exception of the first legs of the Round of 16 matches.

Qualification for the knockout stage of the EPCR Challenge Cup will be decided on the weekend of 8/9/10 April with the Round 5 action in Pool C getting underway on Friday, 8 April when CA Brive meet Saracens at Stade Amédée Domenech live on BT Sport, while Edinburgh Rugby will be up against Section Paloise at the DAM Health Stadium.

To date, RC Toulon, Lyon, Gloucester Rugby and London Irish have booked their places in the Round of 16 along with Cardiff Rugby, Wasps, Castres Olympique, Glasgow Warriors, Northampton Saints and Bath Rugby who have qualified from the Heineken Champions Cup pool stage.

Heineken Champions Cup - Round of 16 first leg
(all kick-offs local times)
Friday 8 April
Connacht Rugby v Leinster Rugby, The Sportsground (20.00)
BT Sport / beIN SPORTS
Saturday 9 April
Sale Sharks v Bristol Bears, AJ Bell Stadium (13.00)
C4 / Virgin Media / BT Sport / beIN SPORTS
Union Bordeaux-Bègles v Stade Rochelais, venue TBC (14.00)
beIN SPORTS / BT Sport
Stade Toulousain v Ulster Rugby, Le Stadium (16.15)
beIN SPORTS / FR 2 / BT Sport
Exeter Chiefs v Munster Rugby, Sandy Park (17.30)
BT Sport / beIN SPORTS
Stade Francais Paris v Racing 92, Stade Jean Bouin (18.30)
beIN SPORTS / BT Sport
Sunday 10 April
Montpellier Hérault Rugby v Harlequins, GGL Stadium (14.00)
beIN SPORTS / BT Sport
ASM Clermont Auvergne v Leicester Tigers, Stade Marcel-Michelin (16.15)
beIN SPORTS / FR 2 / BT Sport

Heineken Champions Cup - Round of 16 second leg
Friday 15 April
Leinster Rugby v Connacht Rugby, Aviva Stadium (17.30)
BT Sport / beIN SPORTS
Bristol Bears v Sale Sharks, Ashton Gate (20.00)
BT Sport / beIN SPORTS
Saturday 16 April
Harlequins v Montpellier Hérault Rugby, Twickenham Stoop (12.30)
C4 / Virgin Media / BT Sport / beIN SPORTS
Munster Rugby v Exeter Chiefs, Thomond Park (15.00)
BT Sport / beIN SPORTS
Stade Rochelais v Union Bordeaux-Bègles, Stade Marcel Deflandre (16.00)
FR 2 / beIN SPORTS / BT Sport
Leicester Tigers v ASM Clermont Auvergne, Mattioli Woods Welford Road (17.30)
BT Sport / beIN SPORTS / FR 4
Ulster Rugby v Stade Toulousain, Kingspan Stadium (20.00)
BT Sport / beIN SPORTS
Sunday 17 April
Racing 92 v Stade Français Paris, Paris La Défense Arena (16.30)
beIN SPORTS / BT Sport

Quarter-finals – 6/7/8 May
The quarter-finals will be played over one match and the highest-ranked clubs from the pool stage will have home venue advantage as follows:
QF 1: Racing 92 (A1) or Stade Francais (B8) v Bristol Bears (B4) or Sale Sharks (A5)
QF 2: Harlequins (B2) or Montpellier (A7) v Stade Rochelais (A3) or Bordeaux-Bègles (B6)
QF 3: Ulster (A2) or Stade Toulousain (B7) v Munster (B3) or Exeter Chiefs (A6)
QF 4: Leicester Tigers (B1) or Clermont (A8) v Leinster (A4) or Connacht (B5)

Semi-finals – 13/14/15 May
The semi-finals will be played over one match, and the highest-ranked clubs from the pool stage will have either home country advantage or home venue advantage (TBC) as follows:
SF 1: Winner QF 1 v Winner QF 2
SF 2: Winner QF 3 v Winner QF 4
2022 Heineken Champions Cup final: Saturday, 28 May; Stade Vélodrome, Marseille (17.45)

EPCR Challenge Cup – Round 5
(all kick-offs local times)
Friday 8 April
Pool C: Edinburgh Rugby v Section Paloise, DAM Health Stadium (20.00)
Pool C: CA Brive v Saracens, Stade Amédée Domenech (21.00)
beIN SPORTS / BT Sport
Saturday 9 April
Pool B: Benetton Rugby v USAP, Stadio Monigo (16.15)
Sky Italia
Pool B: Dragons v Gloucester Rugby, Rodney Parade (20.00)
S4C
Pool A: Newcastle Falcons v Zebre Parma, Kingston Park (20.00)
Pool A: Biarritz Olympique v RC Toulon, Parc des Sports Aguiléra (21.00)
FR 4 / beIN SPORTS
Round of 16 – 15/16/17 April
Quarter-finals – 6/7/8 May
Semi-finals – 13/14/15 May
2022 EPCR Challenge Cup final: Friday, 27 May; Stade Vélodrome, Marseille (21.00)

NB The following clubs have qualified from the Heineken Champions Cup pool stage for the Round of 16 of the EPCR Challenge Cup:
Cardiff Rugby (ranked No 11 for Challenge Cup Round of 16)
Wasps (ranked No 12 for Challenge Cup Round of 16)
Castres Olympique (ranked No 13 for Challenge Cup Round of 16)
Glasgow Warriors (ranked No 14 for Challenge Cup Round of 16)
Northampton Saints (ranked No 15 for Challenge Cup Round of 16)
Bath Rugby (ranked No 16 for Challenge Cup Round of 16)

Click HERE for EPCR Challenge Cup pool tables and HERE for key tournament rules