There were three intriguing encounters on Friday, as Wasps, London Irish, Lyon and Glasgow Warriors all booked their places in the quarter-finals.

A hat-trick of tries from Alfie Barbeary helped Wasps to a 39-29 victory against Biarritz Olympique, with Jacob Umaga and Dan Robson also crossing at Parc des Sports Aguiléra.

Wasps, whose progression was far from certain until Barbeary’s third score on 75 minutes, visit Edinburgh Rugby in the last eight.

London Irish ran in 10 tries to thrash Castres Olympique 64-27 in an incredible contest at Brentford Community Stadium, the TOP 14 side going close to completing an incredible comeback before for the hosts went over four times in the final 10 minutes.

Agustin Creevy (2), Curtis Rona, Tom Pearson, Juan Martin Gonzalez, Kyle Rowe, Matt Rogerson, Will Joseph, Matt Cornish and Benhard Janse van Rensburg all crossed for Irish, who travel to RC Toulon in the quarter-finals.

Lyon proved too strong for Worcester Warriors as they claimed a 31-17 victory at Matmut Stadium de Gerland, Pierre-Louis Barassi's late score sealing their success after Baptiste Couilloud, Romain Taofifénua and Vivien Devisme had got over.

Lyon, who have now won five games from five in the EPCR Challenge Cup this season, host Glasgow in the quarter-finals.

Glasgow, meanwhile, overcame Newcastle Falcons 27-17 at Kingston Park, Kyle Steyn (2), Johnny Matthews and Josh McKay dotting down for the Scottish region.

Newcastle trailed 19-3 at the break but battled back in the second half, however, Glasgow held on to set up their trip to Lyon in the last eight.

On Saturday, Toulon underlined their title credentials as they saw off Benetton Rugby 36-17 at Stade Félix Mayol, Louis Carbonel kicking 21 points for the three-time European champions.

Gabin Villiere, Charles Ollivon and Jules Coulon crossed for the TOP 14 side as they secured their home quarter-final clash with London Irish.

Gloucester Rugby came out on top of a feisty affair with Northampton Saints, triumphing 31-21 in a game which saw one yellow card and two red cards.

Ollie Thorley, Val Rapava-Ruskin, Matías Alemanno and Santiago Socino went over for Gloucester at Kingsholm as they booked a home quarter-final against Saracens.

Elsewhere on Saturday, a strong second-half performance saw Edinburgh ease to a 41-19 victory over Bath Rugby at DAM Health Stadium,

Emiliano Boffelli (2), Blair Kinghorn, Pierre Schoeman, Mark Bennett and Connor Boyle were the Scottish region’s try scorers as they secured their home clash with Wasps in the last eight.

In Sunday’s game, Saracens were made to work hard for their 40-33 win over Cardiff Rugby at StoneX Stadium.

Scores from Sean Maitland (2), Dominic Morris, Aled Davies and Max Malins, plus 15 points from the boot of Owen Farrell, were enough to see the three-time European champions progress and confirm their quarter-final trip to Wasps.

The EPCR Challenge Cup Round of 16 produced a series of pulsating games as the knockout stage of this season’s competition got underway this weekend.