Brown, who won the competition with Harlequins in 2011, will start at full-back at the StoneX Stadium, with former Saracen Nathan Earle and Adam Radwan completing the back three.

Tight-head prop Trevor Davison comes into the Falcons front row, while Sean Robinson returns to the second row and Gary Graham is added to the back row.

Saracens make four changes to their starting XV, with British and Irish Lion prop Mako Vunipola returning to the front row, wing Sean Maitland back from a knee injury, Callum Hunter-Hill coming into the second row and Dom Morris starting at outside centre.

Gloucester Rugby, who entertain Sale Sharks, recall Lions wing Louis Rees-Zammit and centre Chris Harris to their starting XV, while London Irish, who host leaders Leicester Tigers, field captain Matt Rogerson in the back row, Albert Tuisue at No. 8 and Tom Parton at full-back.

Elsewhere, Lions wing Duhan van der Merwe and prop Rory Sutherland make their Worcester Warriors debuts at Exeter Chiefs.

In the United Rugby Championship on Saturday, Zebre meet holders Leinster Rugby at Dublin’s RDS Arena, while Dragons travel to The Sportsground to face Connacht Rugby.

In the TOP 14, EPCR Challenge Cup contenders Biarritz Olympique host Lyon, CA Brive visit RC Toulon and Section Paloise travel to Stade Toulousain.

Challenge Cup winner Mike Brown will make his competitive debut for Newcastle Falcons as they visit Saracens in the Gallagher Premiership on Saturday.