The Samoan centre has featured 35 times in the EPCR Challenge Cup for Cardiff, lifting the trophy in 2018.

Lee-Lo will be looking to help Cardiff take another step towards what would be their third title when they host Sale Sharks in the Round of 16 on April 2.

However, the focus remains on domestic rugby for now as Wales international props Rhys Carré and Dillon Lewis return for Saturday’s game at Cardiff Arms Park.

Elsewhere in the URC, Dragons RFC, who travel to Glasgow Warriors in the EPCR Challenge Cup Round of 16, have three Wales internationals returning as they welcome Connacht Rugby.

Prop Leon Brown, hooker Bradley Roberts and flanker Aaron Wainwright are all back for the Newport-based side.

Centre Max Clark and wing Jared Rosser are also recalled, while hooker Elliot Dee and back-row forward Harrison Keddie return to fitness and are named among the replacements.

No.8 Paul Boyle and wing Shayne Bolton come in as the only changes for Connacht, who are away at Benetton Rugby in the EPCR Challenge Cup Round of 16, with centre Shane Jennings poised to make his debut for the Irish province from the bench.

Benetton and Emirates Lions are two further EPCR Challenge Cup contenders in URC action on Saturday – the Italian team are at Ospreys while the South African outfit are at Vodacom Bulls.

Lock Willem Alberts comes in for Emirates Lions, who host Racing 92 in the EPCR Challenge Cup Round of 16, while an English duo are among those called in by Benetton, in fly-half Jacob Umaga and wing Marcus Watson.

Several EPCR Challenge Cup team features across Saturday’s TOP 14 fixtures, with ASM Clermont Auvergne visiting Montpellier Hérault Rugby, CA Brive hosting Union Bordeaux-Bègles, Lyon travelling to Castres Olympique, while RC Toulon and Stade Français Paris go head-to-head at the Stade Félix Mayol.

Two sides who have dropped out of the Heineken Champions Cup and into the EPCR Challenge Cup are involved in Sunday’s domestic games as Sale Sharks host Saracens in the Gallagher Premiership and Racing 92 entertain Saracens in the TOP 14.

Same James is back at centre for Sale while wing Tom Roebuck makes his 50th appearance for the club.

EPCR Challenge Cup winner Rey Lee-Lo will make his 150th appearance for Cardiff Rugby as they host Ulster Rugby in the United Rugby Championship (URC) on Saturday.