Vunipola, who has three Heineken Champions Cup winners’ medals, lines up at No.8 and is joined in the Saracens back row by Ben Earl and the returning Andy Christie.

In the backs, Rotimi Segun and Max Malins are added to the back three, with fly-half Owen Farrell captaining the side in a half-back duo with Aled Davies.

Gloucester Rugby, who will host Saracens in next weekend’s EPCR Challenge Cup quarter-final clash, have made four changes to their starting XV ahead of their West Country derby against Bath Rugby.

Harry Elrington, Jack Singleton and Kirill Gotovtsev all return for George Skivington’s side and will form the front row at the Kingsholm Stadium, with the only other change coming in the back row as Ben Morgan starts at No.8.

Elsewhere, fellow quarter-finalists Edinburgh Rugby welcome Ulster Rugby to the DAM Health Stadium in the United Rugby Championship, whereas Lyon host Montpellier Hérault Rugby in the TOP 14.

On Sunday, there is an all-EPCR Challenge Cup clash in the Premiership as London Irish take on Wasps at the Brentford Community Stadium. In the TOP 14, RC Toulon head to Union Bordeaux-Bègles.

Saracens back-rower Billy Vunipola is set to make his 150th appearance for the EPCR Challenge Cup quarter-finalists on Saturday as Mark McCall’s side take on Worcester Warriors at Sixways Stadium in the Gallagher Premiership.