May, who won the 2015 Challenge Cup with Gloucester, starts on the left flank for the visitors in a back three with the returning Santiago Carreras and full-back Lloyd Evans.

Mark Atkinson returns to form a midfield partnership with Chris Harris at StoneX Stadium, with Charlie Chapman coming in at fly-half. In the forwards, Alex Seville starts at loosehead prop in a front row with Jack Singleton and Fraser Balmain.

Hosts Saracens welcome Vincent Koch back to the front row, with Tim Swinson returning to the second row with Maro Itoje. Andy Christie starts at No.8 alongside flankers Ben Earl and Nick Isiekwe.

In the backs, Dom Morris starts in midfield with Alex Lozowski and Rotimi Segun replaces Sean Maitland on the right wing.

Meanwhile, Newcastle Falcons have named three changes to the side that lost to 31-0 to Leicester Tigers, with hooker George McGuigan, No.8 Callum Chick and wing Tom Penny all starting as Dean Richards’ side welcome Northampton Saints to the Kingston Park Stadium.

In the United Rugby Championship, Edinburgh Rugby head coach Mike Blair has named six changes, which see Scottish internationals Jamie Ritchie and Grant Gilchrist return to the pack, as the EPCR Challenge Cup side host Cardiff Rugby at BT Murrayfield.

Elsewhere, there will be two all-EPCR Challenge Cup clashes in France’s TOP 14 as Biarritz Olympique take on USAP and Lyon host Section Paloise. Fellow EPCR Challenge Cup side CA Brive face Union Bordeaux-Bègles at Stade Amédée-Doménech.

England international Jonny May will return to the Gloucester Rugby starting line-up as George Skivington’s men travel to fellow EPCR Challenge Cup contenders Saracens in the Gallagher Premiership on Saturday.