Exeter – who sit third in Pool A with one win and one defeat from their opening two fixtures – make two changes from the side who lost to Glasgow Warriors in Round 2.

Sam Skinner moves from the back row into the second row as Jannes Kirsten comes in at openside flanker. The other change for Rob Baxter’s side sees centre Ollie Devoto replace Ian Whitten who drops to the bench.

Bristol – who have a 100% record in Pool B – make three changes with flanker Dan Thomas, No.8 Nathan Hughes and wing Luke Morahan brought in to the XV by director of rugby Pat Lam, while Joe Joyce is handed the captain’s armband.

Another cross-pool contest sees Pool A’s Sale Sharks host Pool B’s Wasps at the AJ Bell Stadium.

Sale welcome back Jono Ross, who will captain the side from flanker, as the only change to the pack which helped the Sharks overcome Ospreys in their one European fixture to date.

Three changes in the backline see scrum-half Will Cliff, full-back Luke James and wing Byron McGuigan inserted into the line-up.

Meanwhile, Wasps head coach Lee Blackett makes three personnel changes and a pair of positional switches – Jimmy Gopperth moves to fly-half to replace the suspended Jacob Umaga, while Sam Spink and Michael Le Bourgeois both return at centre, with Nizaam Carr coming in at openside flanker.

Pool B leaders Harlequins travel to Gloucester Rugby on Sunday – lock Hugh Tizard, fly-half Marcus Smith and centre Luke Northmore are welcomed back into the starting XV as director of rugby Billy Millard makes three changes.

Leicester Tigers, who are hot on the heel of Quins in Pool B after two wins from two, host Newcastle Falcons. George Ford makes his 100th Leicester appearance at fly-half.

Centre Matt Scott and wing Guy Porter come into Steve Borthwick’s XV in the backs, while lock Eli Snyman, flanker Ollie Chessum and No.8 George Martin comprise three changes in the pack.

Elsewhere, Northampton Saints make four changes ahead of their game against Saracens. Piers Francis makes his second start of the campaign at centre, forming an entirely new partnership with Rory Hutchinson in the middle of the backfield.

Paul Hill comes into Chris Boyd’s starting XV at tighthead prop, with 22-year-old Alex Coles featuring at lock.

In the United Rugby Championship, there’s a Pool B battle between Connacht Rugby and Munster Rugby. Connacht make two changes to the side that faced Leicester Tigers in Round 2 – Mack Hansen starts on the wing with Oisín Dowling coming into the second row.

Munster make seven changes to the side who defeated Castres Olympique in Round 2, back-row Alex Kendellen making his first start for the club, while Rory Scannell is in line to make his 150th appearance for the province from the bench.

Two Welsh regions battle it out in another inter-pool battle as Scarlets host Ospreys. Scott Williams skippers a Scarlets side who include Harri O’Connor - who is set to make his URC debut - while Steff Hughes comes in at centre and Steffan Evans gets the nod on the wing.

Ospreys welcome back Keelan Giles for his first appearance since April as head coach Toby Booth makes seven changes from the side who suffered defeat at the hands of Sale in Pool A in December.

There’s also a full list of TOP 14 games in France, Saturday’s showdown between ASM Clermont Auvergne and defending Heineken Champions Cup winners Stade Toulousain the pick of the weekend's action.

Heineken Champions Cup Pool A meets Pool B in the pick of Saturday’s Gallagher Premiership fixtures as 2020 European Cup winners Exeter Chiefs host Bristol Bears at Sandy Park.