The resounding victory ended a five-game winning run for Wasps, who are level on points with Leinster Rugby at the top of Pool A in the Heineken Champions Cup.

Harlequins meanwhile sit second-bottom of Pool B, but it was apparent that the two team’s contrasting form in Europe would have little bearing domestically as Will Evans crossed for the visitors after five minutes.

A further score from Danny Care and two Marcus Smith penalties put Harlequins well in control at the break, with Wasps’ only reply a Lima Sopoaga penalty in the final minute of the half.

Harlequins' dominance continued in the second period with Alex Dombrandt dotting down, before Wasps notched their first try of the day through Zach Kibirige.

Smith, who racked up 15 points over the course of the game, kicked another penalty minutes later before a Lynagh try extended Harlequins' lead further.

Wasps rallied briefly with a Tom Willis score, but Harlequins’ victory never looked in doubt as James Lang crossed shortly after before a late penalty try capped a commanding performance.

Harlequins' third Gallagher Premiership win of the season sees them move level on points with fifth-placed Wasps.

Harlequins racked up six tries as they marched to an impressive 49-17 win away at Wasps in the Gallagher Premiership.