Wales international Beck will line up in midfield with Francois Venter at Sixways Stadium, as Billy Searle, Perry Humphreys and Duhan van der Merwe make up the back three and Gareth Simpson and Fin Smith form the half-back partnership.

In the forwards, Rory Sutherland and Christian Judge come into the front row, with Joe Batley added to the second row as Kyle Hatherell and Ted Hill start in the flanker positions.

Northampton, who qualified for the EPCR Challenge Cup Round of 16 after finishing tenth in Heineken Champions Cup Pool A, make six changes to the side that faced Ulster Rugby on January 16.

Fraser Dingwall captains the side in the centres, with Ollie Sleightholme starting on the right wing and Ahsee Tuala in at full-back.

Api Ratuniyarawa replaces Brandon Nansen in the locks, whereas Tom Wood and Juarno Augustus start at flanker and No.8 respectively.

Meanwhile, fellow EPCR Challenge Cup sides Newcastle Falcons and Gloucester Rugby face each other at Kingston Park.

Newcastle welcome Argentina international Mateo Carreras back to the wing, with his compatriot Matias Orlando coming into the centres.

Hooker George McGuigan comes into the front row and Sean Robinson starts at lock. Philip van der Walt and Will Welch are the starting flankers.

George Skivington’s visitors have named Lloyd Evans and Santiago Carreras in their back three with Ollie Thornley, whereas Billy Twelvetrees starts at centre and Charlie Chapman is in at scrum-half.

Val Rapava-Ruskin and Jack Singleton form the front row with Fraser Balmain and Ruan Ackermann returns at No.8.

In the TOP 14, there are two all-EPCR Challenge Cup matches as CA Brive host Biarritz Olympique and USAP meet Lyon, with Castres Olympique facing Union Bordeaux-Bègles.

In the United Rugby Championship, Zebre Parma host Munster Rugby, whereas Glasgow Warriors travel to Connacht Rugby as Edinburgh Rugby face Ospreys and Cardiff Rugby take on Leinster Rugby.

Worcester Warriors centre Ashley Beck will make his 50th appearance for the club on Saturday as they face Northampton Saints in an all-EPCR Challenge Cup encounter in the Gallagher Premiership.