England will open the defence of their Guinness Six Nations title against Scotland at Twickenham on Saturday with four players from European Rugby Challenge Cup clubs in their starting XV.

Leicester Tigers, who are fourth in the Preliminary Stage standings this season, provide two in scrum-half Ben Youngs and loose-head prop Ellis Genge, while Worcester Warriors and Newcastle Falcons have one apiece in inside centre Ollie Lawrence and blind-side flanker Mark Wilson respectively.

Youngs, who will win his 105th cap, is the most experienced player in the England team and the 21-year-old Lawrence the least, as he is set to play in only his fourth Test and makes his first Six Nations start.

Wilson, 31, will make his first England appearance since last March and his 20th in total, while Genge will win his 24th cap.

However, there is no place in the starting XV for Leicester Tigers fly-half George Ford. The 27-year-old, who has played in 72 Tests, is on the bench.

Meanwhile, France have selected only one Challenge Cup player – experienced Stade Français Paris centre Gaël Fickou – in their starting XV for their game against Italy in Rome on Saturday. Castres Olympique flanker Anthony Jelonch is a replacement, though.