One of the most historic European clashes gets the knockout stage under way on Friday evening as four-time winners Leinster Rugby take on three-time European champions RC Toulon in a mouthwatering tie at The RDS, live from 17:30 (all matches are UK time and live on BT Sport).

The second helping of Good Friday action sees Gloucester Rugby face off against 2019 Challenge Cup finalists La Rochelle at 20:00, with a home quarter-final on the line for the winners of that match.

We then roll into a super Saturday of Heineken Champions Cup action, with our free-to-air match on Channel 4 and Virgin Media featuring Wasps and ASM Clermont Auvergne, live from the Ricoh Arena at 12:30.

Arguably the tie of the Last 16 sits as the main course on Saturday, with two-time winners Munster Rugby hosting a star-studded Toulouse side with the likes of scrum-half Antoine Dupont looking to take his side one step further after last season’s semi-final exit at the hands of Exeter Chiefs. You can watch that clash from Thomond Park at 15:00.

Rounding off the Saturday action is the aforementioned Exeter Chiefs who take on Lyon at Sandy Park, with their European defence continuing at 17:30.

A tasty trio of matches take place on Sunday, with last season’s finalists Racing 92 facing Edinburgh Rugby at Paris La Defense Arena at 12:30 before a repeat of last season’s Challenge Cup semi-final classic between Bordeaux-Begles and Bristol Bears at 15:00.

And the final match of the weekend pits Welsh region Scarlets against Sale Sharks, live from Parc y Scarlets at 17:30.

The Heineken Champions Cup returns this weekend with an expanded knockout stage as 16 teams are set to do battle and attempt to move one step closer to Europe’s top club prize.